Carrier

From The School of Biomedical Sciences Wiki
Jump to navigation Jump to search
The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.

A carrier is an organism that carries a disease without showing any symptoms. If the disease is genetic, the carrier will be heterozygous, with a dominant, healthy allele and a reccessive allele for the disease state. In the event of two carriers mating, there is a 25% chance their offspring will be affected by the disease, 50% chance of the offspring being carriers or a 25% chance of the offspring being healthy and not a carrier[1].

An example of this is Cystic Fibrosis, where 1 in 25 of the white population are carriers of the CF gene, showing no signs of having CF themselves.

A Punnett Square showing two carriers mating: (H is healthy, dominant allele, he is recessive for disease state) indicates how alleles from each parent cross.

H h
H HH Hh
h Hh hh

References

  1. D.L. Hartl, E.W.Jones.(2000)Genetics: analysis of genes and genomes, 5th edition. Sudbury, Jones and Bartlett publishers