Pronounced alpha-ketoglutarate dehydrogenase, this is a complex formed from three kinds of enzymes found in the citric acid cycle (CAC).
It catalyses the oxidative decarboxylation of alpha-ketoglutarate to succinyl CoA.
The reaction is as follows:
alpha-Ketoglutarate + NAD + CoA -----► Succinyl CoA + CO2 + NADH
- ↑ Berg J, Tymoczko J, Gatto G, Stryer L. Biochemistry. 8th ed. New York: W.H. Freeman; 2015. p. 505