1-6 glycosidic bond

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&nbsp;An α-1,6-[[Glycosidic_bond|glycosidic bond]] is a [[Covalent|covalent]] bond formed between the -OH group on [[Carbon|carbon]] 1 of one [[Sugar|sugar]] and the -OH group on [[Carbon|carbon]] 6 of another sugar. This linkage causes branching&nbsp;within the [[Polysaccharide|polyscaccharide]]. <sup>[1] </sup>Formation of a [[Glycosidic_bond|glycosidic bond]] is a [[Condensation_Reaction|condensation]] reaction as a [[Molecule|molecule]] of [[Water|water]] is released, thus the bond can be broken by a molecule of [[Water|water]] in a [[Hydrolysis|hydrolysis]] reaction.<sup>[2]</sup> α-1,6-[[Glycosidic_bonds|glycosidic bonds]] can be found in [[Amylopectin|amylopectin]] and [[Glycogen|glycogen]] which are both [[storage molecules|storage molecules]] composed of α-[[Glucose|glucose]]&nbsp;. Whilst most of the [[Glucose|glucose]] units in [[Amylopectin|amylopectin]] and [[Glycogen|glycogen]] are linked by [[1,4_glycosidic_bonds|α-1,4- glycosidic bonds]], the branches are formed by α-1,6 glycosidic bonds, which occur around once every ten units in [[Glycogen|glycogen]] and once every thirty in [[Amylopectin|amylopectin]], thus, [[Glycogen|glycogen]] is more extensively branched.<sup>[1]</sup>
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An α-1,6-[[Glycosidic bond|glycosidic bond]] is a [[Covalent|covalent]] bond formed between the -OH group on [[Carbon|carbon]] 1 of one [[Sugar|sugar]] and the -OH group on [[Carbon|carbon]] 6 of another sugar. This linkage causes branching&nbsp;within the [[Polysaccharide|polyscaccharide]]&nbsp;<ref>Stryer, L. (1988) Biochemistry. 3rd edn. New York: W. H. Freeman. 341-342</ref>.<sup>&nbsp;</sup>Formation of a [[Glycosidic bond|glycosidic bond]] is a [[Condensation Reaction|condensation]] reaction as a [[Molecule|molecule]] of [[Water|water]] is released, thus the bond can be broken by a molecule of [[Water|water]] in a [[Hydrolysis|hydrolysis]] reaction&nbsp;<ref>Bruce, A, Johnson, A, Lewis, J, Raff, M, Roberts, K and Walter, P. (2008). Molecular Biology of the Cell. 5th ed. New York: Garland Science. 56-57</ref>.&nbsp;α-1,6-[[Glycosidic bonds|glycosidic bonds]] can be found in [[Amylopectin|amylopectin]] and [[Glycogen|glycogen]] which are both [[Storage molecules|storage molecules]] composed of α-[[Glucose|glucose]]&nbsp;. Whilst most of the [[Glucose|glucose]] units in [[Amylopectin|amylopectin]] and [[Glycogen|glycogen]] are linked by [[1,4 glycosidic bonds|α-1,4- glycosidic bonds]], the branches are formed by α-1,6 glycosidic bonds, which occur once every ten units in [[Glycogen|glycogen]] and once every thirty in [[Amylopectin|amylopectin]], thus, [[Glycogen|glycogen]] is more extensively branched&nbsp;<ref>Stryer, L. (1988) Biochemistry. 3rd edn. New York: W. H. Freeman. 341-342</ref>  
  
References<br>1.&nbsp;Stryer, L. (1988) Biochemistry. 3rd edn. New York: W. H. Freeman. 341-342<br>2. Bruce, A, Johnson, A, Lewis, J, Raff, M, Roberts, K and Walter, P. (2008). Molecular Biology of the Cell. 5th ed. New York: Garland Science. 56-57
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Latest revision as of 14:39, 18 October 2016

An α-1,6-glycosidic bond is a covalent bond formed between the -OH group on carbon 1 of one sugar and the -OH group on carbon 6 of another sugar. This linkage causes branching within the polyscaccharide [1]. Formation of a glycosidic bond is a condensation reaction as a molecule of water is released, thus the bond can be broken by a molecule of water in a hydrolysis reaction [2]. α-1,6-glycosidic bonds can be found in amylopectin and glycogen which are both storage molecules composed of α-glucose . Whilst most of the glucose units in amylopectin and glycogen are linked by α-1,4- glycosidic bonds, the branches are formed by α-1,6 glycosidic bonds, which occur once every ten units in glycogen and once every thirty in amylopectin, thus, glycogen is more extensively branched [3]

References

  1. Stryer, L. (1988) Biochemistry. 3rd edn. New York: W. H. Freeman. 341-342
  2. Bruce, A, Johnson, A, Lewis, J, Raff, M, Roberts, K and Walter, P. (2008). Molecular Biology of the Cell. 5th ed. New York: Garland Science. 56-57
  3. Stryer, L. (1988) Biochemistry. 3rd edn. New York: W. H. Freeman. 341-342
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