ABC Superfamily

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The ABC Superfamily stands for ATP Binding Cassette Family. These proteins are invloved in ion transport across the memberane, with members including CFTR AND P-Glycoprotein. The standard structure of a member of the ABC is 12 membrane-spanning domains and 2 Nucleotide Binding Domains (occassionally referred to as a Nucleotide Folding Domain).

The ABC family of proteins are one of the largest family of proteins known and have been found in both prokaryotes and eukaryotes.These family of proteins differ significantly from other ATP-binding protein family of kinases. They are not all involved in ion transport across the membrane, some have also been found to be involved in the presentation of antigens as well as being involved in different inherited human diseases.[1]


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