ABC superfamily

From The School of Biomedical Sciences Wiki
Jump to: navigation, search

ATP-binding cassette transporters are transmembrane proteins that use energy from ATP to carry out biological processes such as translocation of substrate across membranes as well as DNA and RNA repair

ABC proteins are the largest family of transmembrane proteins, they contain two nucleotide binding domains, located in the cytoplasm, and two transmembrane domains[1]
An example of ABC superfamily is the cystic fibrosis transmembrane conductance regulator. Yet, it is very exclusive as it is an ion pump and not an ATPase pump which most ABCs are. 


  1. Dean M. The Human ATP-Binding Cassette (ABC) Transporter Superfamily [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2002 Nov 18. Available from:
Personal tools