AIRE

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Aire is an auto immune regulator protein, which plays an essential role in promoting self-tolerance in the [[Thymus|thymus]].  
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AIRE is an auto immune regulator protein, which plays an essential role in promoting self-tolerance in the [[Thymus|thymus]].  
  
It is expressed in the thymus and turns on specific [[gene|genes]] which would not normally expressed in the thymus. In this way it allows for the deletion of [[T-cells|T-cells]] which recognise tissue-specific [[antigen|antigen]], that are being unusually expressed in the thymus.  
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It is expressed in the thymus and turns on specific [[Gene|genes]] which wouldn't normally be expressed in the thymus. In this way, it allows for the deletion of [[T-cells|T-cells]] which recognise tissue-specific [[Antigen|antigen]], that are being unusually expressed in the thymus.  
  
Major [[Autoimmune disease|autoimmune syndromes]] would result from the deficiency of aire.
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Major [[Autoimmune disease|autoimmune syndromes]] would result from the deficiency of AIRE.

Latest revision as of 19:20, 22 October 2018

AIRE is an auto immune regulator protein, which plays an essential role in promoting self-tolerance in the thymus.

It is expressed in the thymus and turns on specific genes which wouldn't normally be expressed in the thymus. In this way, it allows for the deletion of T-cells which recognise tissue-specific antigen, that are being unusually expressed in the thymus.

Major autoimmune syndromes would result from the deficiency of AIRE.

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