AIRE

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AIRE is an auto immune regulator protein, which plays an essential role in promoting self-tolerance in the thymus.

It is expressed in the thymus and turns on specific genes which wouldn't normally be expressed in the thymus. In this way, it allows for the deletion of T-cells which recognise tissue-specific antigen, that are being unusually expressed in the thymus.

Major autoimmune syndromes would result from the deficiency of AIRE.

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