ATM is a protein kinase which recognises DNA damage and plays an important role in the DNA damage response system. ATM is homologous to another protein kinase called ATR; ATM and ATR recruit adaptor proteins and other protein kinases called Chk1 and Chk2. Chk1 and Chk2 then initiate repair and cause apoptosis or cell cycle arrest. ATM only responds to double-strand breaks, therefore it is very specialised.
- ↑ H. Lodish, C. A. Kaiser, A. Berk, M. Krieger, A. Bretscher, H. Ploegh, A. Amon, M. P. Scott. Molecular Cell Biology. 7th Ed. New York: W. H. Freeman. 2013.