Abc transporter protein

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ABC transporters are one of the largest families (a superfamily) of transport [[Proteins|proteins]], that transport a wide variety of molecules ranging from small [[Ions]]&nbsp;to large&nbsp;[[macromolecules]]<span style="line-height: 1.5em;">. ABC transporters are typically composed of 4 main domains, these consist of 2 catalytic </span>[[ATPase domain|ATPase domains]]<span style="line-height: 1.5em;">&nbsp;(also known as ABC)</span><span style="line-height: 1.5em;">&nbsp;and 2 </span>[[transmembrane domains]]<span style="line-height: 1.5em;">.<ref>http://www.ebi.ac.uk/interpro/entry/IPR010067</ref> W</span><span style="line-height: 1.5em;">hen </span>[[ATP|ATP]]<span style="line-height: 1.5em;"> binds to the ABC modules,&nbsp;</span><span style="line-height: 1.5em;">the two domains dimerize, and when ATP is hydrolyzed they dissociate. The conformational change in the ABC transporter results in a change in the membrane itself, revealing a substrate binding site. This is thought to be how ABC transporters move small molecules across membranes.</span><ref>Alberts, B et al., 2007. Molecular Biology of the Cell, 5th edition. Garland Science, pg. 663</ref>
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ABC transporters are one of the largest families (a superfamily) of transport [[Proteins|proteins]], that transport a wide variety of molecules ranging from small [[Ions]]&nbsp;to large&nbsp;[[Macromolecules]]<span style="line-height: 1.5em;">. ABC transporters are typically composed of 4 main domains, these consist of 2 catalytic </span>[[ATPase domain|ATPase domains]]<span style="line-height: 1.5em;">&nbsp;(also known as ABC)</span><span style="line-height: 1.5em;">&nbsp;and 2 </span>[[Transmembrane domains]]<span style="line-height: 1.5em;">.<ref>http://www.ebi.ac.uk/interpro/entry/IPR010067</ref> W</span><span style="line-height: 1.5em;">hen </span>[[ATP|ATP]]<span style="line-height: 1.5em;"> binds to the ABC modules,&nbsp;</span><span style="line-height: 1.5em;">the two domains dimerize, and when ATP is hydrolyzed they dissociate. The conformational change in the ABC transporter results in a change in the membrane itself, revealing a substrate binding site. This is thought to be how ABC transporters move molecules across membranes.</span><ref>Alberts, B et al., 2007. Molecular Biology of the Cell, 5th edition. Garland Science, pg. 663</ref>  
  
ABC transporters are found in all species of animals, from humans all the way down to simple single-celled microbes.
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ABC transporters are found in all species of animals, from humans all the way down to simple single-celled microbes.  
  
 
=== References  ===
 
=== References  ===

Latest revision as of 18:01, 21 October 2014

ABC transporters are one of the largest families (a superfamily) of transport proteins, that transport a wide variety of molecules ranging from small Ions to large Macromolecules. ABC transporters are typically composed of 4 main domains, these consist of 2 catalytic ATPase domains (also known as ABC) and 2 Transmembrane domains.[1] When ATP binds to the ABC modules, the two domains dimerize, and when ATP is hydrolyzed they dissociate. The conformational change in the ABC transporter results in a change in the membrane itself, revealing a substrate binding site. This is thought to be how ABC transporters move molecules across membranes.[2]

ABC transporters are found in all species of animals, from humans all the way down to simple single-celled microbes.

References

  1. http://www.ebi.ac.uk/interpro/entry/IPR010067
  2. Alberts, B et al., 2007. Molecular Biology of the Cell, 5th edition. Garland Science, pg. 663


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