Abc transporter protein
ABC transporters are one of the largest families (a superfamily) of transport proteins, that transport a wide variety of molecules ranging from small Ions to large macromolecules. ABC transporters are typically composed of 4 main domains, these consist of 2 catalytic ATPase domains (also known as ABC) and 2 transmembrane domains. When ATP binds to the ABC modules, the two domains dimerize, and when ATP is hydrolyzed they dissociate. The conformational change in the ABC transporter results in a change in the membrane itself, revealing a substrate binding site. This is thought to be how ABC transporters move small molecules across membranes.
ABC transporters are found in all species of animals, from humans all the way down to simple single-celled microbes.
- ↑ http://www.ebi.ac.uk/interpro/entry/IPR010067
- ↑ Alberts, B et al., 2007. Molecular Biology of the Cell, 5th edition. Garland Science, pg. 663