Acetyl CoA

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Acetyl CoA (acetyl Coenzyme A) is an intermediary involved in the metabolism of glucose, fatty acids and proteins. It is synthesised&nbsp;by the esterfication of [[Acetate|acetate]] and the intermediates in [[fatty acid biosynthesis|fatty acid biosynthesis]]&nbsp;<ref name="null">Lodish, Berk, Kaiser, Krieger, Scott, Bretscher, Ploegh (2008) Molecular Cell Biology 6th edition 10:430</ref>.&nbsp;<br>  
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Acetyl CoA (acetyl Coenzyme A) is an intermediary involved in the metabolism of [[Glucose|glucose]], fatty acids and proteins. It is synthesised&nbsp;by the esterfication of [[Acetate|acetate]] and the intermediates in [[Fatty acid biosynthesis|fatty acid biosynthesis]]&nbsp;<ref name="null">Lodish, Berk, Kaiser, Krieger, Scott, Bretscher, Ploegh (2008) Molecular Cell Biology 6th edition 10:430</ref>.&nbsp;<br>
  
Saturated fatty acids are made from acetyl CoA by two enzymes - [[Acetyl-CoA carboxylase|acetyl-CoA carboxylase]] and&nbsp;[[Fatty acid synthesase|fatty acid synthase]]<ref>Lodish, Berk, Kaiser, Krieger, Scott, Bretscher, Ploegh (2008) Molecular Cell Biology 6th edition 10:430</ref>&nbsp;which are found in the [[Cytosol|cytosol]] of animal cells.<br>  
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Saturated fatty acids are made from acetyl CoA by two enzymes - [[Acetyl-CoA carboxylase|acetyl-CoA carboxylase]] and&nbsp;[[Fatty acid synthesase|fatty acid synthase]]<ref>Lodish, Berk, Kaiser, Krieger, Scott, Bretscher, Ploegh (2008) Molecular Cell Biology 6th edition 10:430</ref>&nbsp;which are found in the [[Cytosol|cytosol]] of animal cells.<br>
  
When [[Pyruvate|pyruvate]] is produced by [[Glycolysis|glycolysis]], it reacts with [[Coenzyme A|coenzyme A]], forming CO<sub>2</sub>, [[NADH|NADH]] and acetyl CoA in the [[Mitochondrial matrix|mitochondrial matrix]].<br>  
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When [[Pyruvate|pyruvate]] is produced by [[Glycolysis|glycolysis]], it reacts with [[Coenzyme A|coenzyme A]], forming CO<sub>2</sub>, [[NADH|NADH]] and acetyl CoA in the [[Mitochondrial matrix|mitochondrial matrix]].<br>
  
In [[Aerobic_respiration|aerobic]] conditions, the acetyl group of acetyl CoA is almost always oxidised to CO<sub>2</sub> via the [[Citric Acid Cycle|citric acid cycle]], in the [[Mitochondria|mitochondria]].<ref>Lodish, Berk, Kaiser, Krieger, Scott, Bretscher, Ploegh (2008) Molecular Cell Biology 6th edition 10:487</ref>  
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In [[Aerobic respiration|aerobic]] conditions, the acetyl group of acetyl CoA is almost always oxidised to CO<sub>2</sub> via the [[Citric Acid Cycle|citric acid cycle]], in the [[Mitochondria|mitochondria]].<ref>Lodish, Berk, Kaiser, Krieger, Scott, Bretscher, Ploegh (2008) Molecular Cell Biology 6th edition 10:487</ref>  
  
 
=== References  ===
 
=== References  ===
  
 
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Revision as of 14:40, 19 October 2012

Acetyl CoA (acetyl Coenzyme A) is an intermediary involved in the metabolism of glucose, fatty acids and proteins. It is synthesised by the esterfication of acetate and the intermediates in fatty acid biosynthesis [1]

Saturated fatty acids are made from acetyl CoA by two enzymes - acetyl-CoA carboxylase and fatty acid synthase[2] which are found in the cytosol of animal cells.

When pyruvate is produced by glycolysis, it reacts with coenzyme A, forming CO2, NADH and acetyl CoA in the mitochondrial matrix.

In aerobic conditions, the acetyl group of acetyl CoA is almost always oxidised to CO2 via the citric acid cycle, in the mitochondria.[3]

References

  1. Lodish, Berk, Kaiser, Krieger, Scott, Bretscher, Ploegh (2008) Molecular Cell Biology 6th edition 10:430
  2. Lodish, Berk, Kaiser, Krieger, Scott, Bretscher, Ploegh (2008) Molecular Cell Biology 6th edition 10:430
  3. Lodish, Berk, Kaiser, Krieger, Scott, Bretscher, Ploegh (2008) Molecular Cell Biology 6th edition 10:487
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