Acute lymphoblastic leukemia

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Acute Lymphoblastic Leukemia is an aggressive form of cancer of the white blood cells, it develops slowly but once symptoms show it rapidly becomes worse. It is a rare type of cancer as only 650 people in the UK on average are diagnosed with it each year. This type of leukemia is the most common type of childhood leukemia[1] .


Acute lymphoblastic leukemia is cause by a mutation the stem cells[1], causing them to produce too many immature white blood cells, called lymphoblasts. These lymphoblasts collect in the bone marrow meaning that the stem cells are unable to produce normal blood cells[2].  The canceer devleops becuase the number of lymphoblasts increases, therefore the number of red blood cells and platelet cells decrease[1]. This means that there are fewer red blood cells carrying oxygen to muscles and respiring cells leading to the symptom of tiredness. The nubmer of platelet cells being produced decreasing means that excessive bleeding can be an issue, as platelets aid the blood in clotting. 


- Tiredness and breathlessness

- Frequent infections due to the lymphoblasts being less effective than normal white blood cells at fighting off infection

- Pale skin

- Frequent infections

- Nosebleeds

-Night sweats

- Bone and joint pain

- Weight loss 

- Abdominal pain due to the liver or the spleen swelling 


Risk factors

- Previous chemotherapy

- Smoking 

- Overweight

- HIV and AIDS



There are three stages to the treatment of Acute lymphoblastic leukemia:

1. Induction. This is where the leukemia cells in your bone marrow are destroyed. 

2. Consolidation. This aims to kill any leukemia cells in your CNS. 

3. Maintenance. This is where you have regular doses of chemotherapy tablets to prevents leukemia returning. 





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