Allosteric sites, are regions on an enzyme at which molecules bind too in order to denature said enzyme. These regions are found seperate and away from the active site of an enzyme and are often found on different polypeptide chains to the active site . They are disitnct regions of the polypeptide chain which certain inhibitor molecules are able to recognise and bind too. If an inhibitor molecule binds to an allosteric site then the enzyme undergoes a conformational change and the enzyme structure changes so therefore the active site shapee changes, thus meaning it cannot bind to its substrate. It is said to be denatured. the changes casued by allosteric binding are said to be final and irreversible  as any allosteric binding leads to an inability to form an enzyme substrate complex.