Amide bond

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An amide bond is a peptide bond. It is formed when the amine group of one amino acid forms a bond with the carboxyl group of another amino acid, resulting in the loss of a single water molecule<ref>Brenner S, Miller JH. Encyclopedia of Genetics. Academic Press. 2001.</ref>.&nbsp;
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An amide bond is a [[peptide bond|peptide bond]]. It is formed when the [[amine group|amine group]] of one [[amino acid|amino acid]] forms a bond with the [[carboxyl group|carboxyl group]] of another amino acid, resulting in the loss of a single [[water|water]] [[molecule|molecule]]<ref>Brenner S, Miller JH. Encyclopedia of Genetics. Academic Press. 2001.</ref>.  
  
The peptide group (–CO–NH–) has partial double-bond characteristics due to the resonance of amides, where the nitrigen atom of the amide group is able to donate its lone pair of electrons to the carbon atom in the carboxyl group and push the electrons from the carbonyl C=O double bond towrds the oxygen atom, which forms an oxygen anion<ref>WikiBooks. Structural Biochemistry/Organic Chemistry/Important Organic Reactions in Biochemistry/Peptide Bonding. 2012 [cited 05/12/18]. Available from: https://en.wikibooks.org/wiki/Structural_Biochemistry/Organic_Chemistry/Important_Organic_Reactions_in_Biochemistry/Peptide_Bonding</ref>.&nbsp;
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The peptide group (–CO–NH–) has partial [[Double_bond|double-bond]] characteristics due to the resonance of [[amides|amides]], where the [[nitrogen|nitrogen]] [[atom|atom]] of the [[amide group|amide group]] is able to donate its lone pair of [[electrons|electrons]] to the [[carbon|carbon]] atom in the carboxyl group and push the electrons from the [[Carbonyl_group|carbonyl]] C=O double bond towrds the [[oxygen|oxygen]] atom, which forms an oxygen [[anion|anion]]<ref>WikiBooks. Structural Biochemistry/Organic Chemistry/Important Organic Reactions in Biochemistry/Peptide Bonding. 2012 [cited 05/12/18]. Available from: https://en.wikibooks.org/wiki/Structural_Biochemistry/Organic_Chemistry/Important_Organic_Reactions_in_Biochemistry/Peptide_Bonding</ref>.  
  
The resonance double bond increases the stability and decreases the rotation about the peptide bond<ref>WikiBooks. Structural Biochemistry/Organic Chemistry/Important Organic Reactions in Biochemistry/Peptide Bonding. 2012 [cited 05/12/18]. Available from: https://en.wikibooks.org/wiki/Structural_Biochemistry/Organic_Chemistry/Important_Organic_Reactions_in_Biochemistry/Peptide_Bonding</ref>.
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The resonance double bond increases the stability and decreases the rotation about the peptide bond<ref>WikiBooks. Structural Biochemistry/Organic Chemistry/Important Organic Reactions in Biochemistry/Peptide Bonding. 2012 [cited 05/12/18]. Available from: https://en.wikibooks.org/wiki/Structural_Biochemistry/Organic_Chemistry/Important_Organic_Reactions_in_Biochemistry/Peptide_Bonding</ref>.  
  
= '''References''' =
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=== References ===
  
 
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Latest revision as of 09:40, 8 December 2018

An amide bond is a peptide bond. It is formed when the amine group of one amino acid forms a bond with the carboxyl group of another amino acid, resulting in the loss of a single water molecule[1].

The peptide group (–CO–NH–) has partial double-bond characteristics due to the resonance of amides, where the nitrogen atom of the amide group is able to donate its lone pair of electrons to the carbon atom in the carboxyl group and push the electrons from the carbonyl C=O double bond towrds the oxygen atom, which forms an oxygen anion[2].

The resonance double bond increases the stability and decreases the rotation about the peptide bond[3].

References

  1. Brenner S, Miller JH. Encyclopedia of Genetics. Academic Press. 2001.
  2. WikiBooks. Structural Biochemistry/Organic Chemistry/Important Organic Reactions in Biochemistry/Peptide Bonding. 2012 [cited 05/12/18]. Available from: https://en.wikibooks.org/wiki/Structural_Biochemistry/Organic_Chemistry/Important_Organic_Reactions_in_Biochemistry/Peptide_Bonding
  3. WikiBooks. Structural Biochemistry/Organic Chemistry/Important Organic Reactions in Biochemistry/Peptide Bonding. 2012 [cited 05/12/18]. Available from: https://en.wikibooks.org/wiki/Structural_Biochemistry/Organic_Chemistry/Important_Organic_Reactions_in_Biochemistry/Peptide_Bonding
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