Angiotensin II

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Angiotensin II is a hormone which is involved in cardiovascular homeostasis. Angiotensin II is a vasoconstrictor and therefore regulates blood pressure by controlling the sympathetic nerves in the kidney[1].

Angiotensin II is produced when the angiotensin-converting enzyme (ACE) removes two amino acids from Angiotensin I[2].

Due to the crucial roles, it plays in heart failure, diabetes and hypertension, there has been the development of some pharmaceutical drugs (e.g. angiotensin II receptor antagonists). These drugs can then be used in the clinical setting to treat hypertension and congestive heart failure[3].


  1. Fyhrquist F1, Metsärinne K, Tikkanen I. J Hum Hypertens. 1995 Nov;9 Suppl 5:S19-24.
  2. National Center for Biotechnology Information. PubChem Compound Database; CID=172198, (accessed Oct. 24, 2018).
  3. ahajounals(2003)Angiotensin II [Internet], 92. Newcastle University, Circulation Research. Available from: [Accessed 19 October 2015].
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