Anticodon

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The anti codon provides the intermediate between transcribed [[MRNA|mRNA]] and the final product of a translated [[Polypeptide|polypeptide]]. The three [[base]] sequence on a molecule of [[TRNA|tRNA]]&nbsp;which is complementary to a codon on a strand of [[MRNA|mRNA]]. The anti codon is located upon neither the D nor T loops of the folded [[TRNA|tRNA]] structure but on the end of the loop next to the variable arm. (See fig 30.3 on referenced page)<ref>Stryer et al (2012) Biochemistry, 7th Edition, New York, Palgrave Macmillan pp924</ref>&nbsp;The [[MRNA|mRNA]] [[Codon|codons]] involved with the anti codon are read 5’-3’&nbsp;<ref>Stryer et al (2012) Biochemistry, 7th Edition, New York, Palgrave Macmillan pp922</ref>.  
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The anti codon provides the intermediate between transcribed [[MRNA|mRNA]] and the final product of a translated [[Polypeptide|polypeptide]]. The three [[Base|Base]] sequence on a molecule of [[TRNA|tRNA]]&nbsp;which is complementary to a codon on a strand of [[MRNA|mRNA]]. The anti codon is located upon neither the D nor T loops of the folded [[TRNA|tRNA]] structure but on the end of the loop next to the variable arm. (See fig 30.3 on referenced page)<ref>Stryer et al (2012) Biochemistry, 7th Edition, New York, Palgrave Macmillan pp924</ref>&nbsp;The [[MRNA|mRNA]] [[Codon|codons]] involved with the anti codon are read 5’-3’&nbsp;<ref>Stryer et al (2012) Biochemistry, 7th Edition, New York, Palgrave Macmillan pp922</ref>.  
  
 
The recognition of an anticodon to a [[Codon|codon]] allows an [[Amino acid|amino acid]] to be brought to a elongating strand of [[Protein|protein]] and joined to it.  
 
The recognition of an anticodon to a [[Codon|codon]] allows an [[Amino acid|amino acid]] to be brought to a elongating strand of [[Protein|protein]] and joined to it.  
  
The first two bases must be completely [[complementary]] to the [[Codon|codon]] to allow [[Hydrogen bonds|hydrogen bonds]] to form between the [[Base pairs|base pairs]], the third base may be non-complementry or modified base (i.e. [[Inosine|inosine]]) but will still form a [[Hydrogen bonds|hydrogen bond]] between the anticodon and [[Codon|codon]],&nbsp;<ref>Molecular Biology of the Cell, 5th edn, Alberts et al., 2008</ref>&nbsp;This is known as the ‘[[Wobble Hypothesis|Wobble Hypothesis]]’ proposed by&nbsp;[[Francis Crick|Francis Crick]]&nbsp;<ref>Stryer et al (2012) Biochemistry, 7th Edition, New York, Palgrave Macmillan pp925</ref>. Due to this property It is down to the anti-codon that the host [[TRNA|tRNA]] may recognise multiple codons.<br>  
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The first two bases must be completely [[Complementary|Complementary]] to the [[Codon|codon]] to allow [[Hydrogen bonds|hydrogen bonds]] to form between the [[Base pairs|base pairs]], the third base may be non-complementry or modified base (i.e. [[Inosine|inosine]]) but will still form a [[Hydrogen bonds|hydrogen bond]] between the anticodon and [[Codon|codon]],&nbsp;<ref>Molecular Biology of the Cell, 5th edn, Alberts et al., 2008</ref>&nbsp;This is known as the ‘[[Wobble Hypothesis|Wobble Hypothesis]]’ proposed by&nbsp;[[Francis Crick|Francis Crick]]&nbsp;<ref>Stryer et al (2012) Biochemistry, 7th Edition, New York, Palgrave Macmillan pp925</ref>. Due to this property It is down to the anti-codon that the host [[TRNA|tRNA]] may recognise multiple codons.<br>  
  
 
=== References<br>  ===
 
=== References<br>  ===
  
 
<references />
 
<references />

Revision as of 12:04, 6 December 2017

The anti codon provides the intermediate between transcribed mRNA and the final product of a translated polypeptide. The three Base sequence on a molecule of tRNA which is complementary to a codon on a strand of mRNA. The anti codon is located upon neither the D nor T loops of the folded tRNA structure but on the end of the loop next to the variable arm. (See fig 30.3 on referenced page)[1] The mRNA codons involved with the anti codon are read 5’-3’ [2].

The recognition of an anticodon to a codon allows an amino acid to be brought to a elongating strand of protein and joined to it.

The first two bases must be completely Complementary to the codon to allow hydrogen bonds to form between the base pairs, the third base may be non-complementry or modified base (i.e. inosine) but will still form a hydrogen bond between the anticodon and codon[3] This is known as the ‘Wobble Hypothesis’ proposed by Francis Crick [4]. Due to this property It is down to the anti-codon that the host tRNA may recognise multiple codons.

References

  1. Stryer et al (2012) Biochemistry, 7th Edition, New York, Palgrave Macmillan pp924
  2. Stryer et al (2012) Biochemistry, 7th Edition, New York, Palgrave Macmillan pp922
  3. Molecular Biology of the Cell, 5th edn, Alberts et al., 2008
  4. Stryer et al (2012) Biochemistry, 7th Edition, New York, Palgrave Macmillan pp925
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