Antisense DNA

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Double-stranded DNA composed of two strands which are antisense and sense strands[1]. Antisense DNA are the strands that are complementary to mRNA and act as the template for it. Antisense DNA can be known as non-coding strand because it contains anti-codon that carries necessary information for the production of proteins by binding to mRNA. For example, 3'-TAC-5' in the antisense DNA acts as a template for mRNA to produce 5'-AUG-3' which is a start codon (methionine) that initiates the translation protein process. Therefore, antisense DNA is important to act as a template for protein translation. Antisense DNA can be also known as minus strand. Non-coding DNA strand which is antisense DNA that does not have the same reading direction sequence with mRNA is called minus strand. Codon strand is plus strand as when we read mRNA in the direction of 5' to 3', it is going to be same as codon strand with same nucleotides. Antisense DNA can be called as non-coding, minus and template strand as well.


  1. Medical Definition of Antisense DNA [Internet]. MedicineNet. 2017 [cited 5 December 2017]. Available from:
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