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BRCA1 or BRCA-1 is a tumour repressor gene[1]. It is involved in DNA repair and transcriptional regulation in response to DNA damage. In humans the BRCA1 gene is located on chromosome 17 and BRCA1 protein is made up of 1863 amino acids[2]. A mutation in BRCA1 genes predisposes to breast and ovarian cancer in women. This is because it encodes important components of the DNA-break systems and so a cell lacking this gene is unable to repair DNA where the homologous chromosome is providing the template for repair[3].


  1. Kiyotsugu Y, Yoshio M. Role of BRCA1 and BRCA2 as regulators of DNA damage repair, transcription and cell cycle in response to DNA damage. Cancer Science Volume 95, issue 11. August 2005.
  2. Duncan J A, Reeves JR, Cooke T G. BRCA1 and BRCA2 Proteins: roles in health and disease. Molecular Pathology 1998;51:237-247.
  3. Lodish H, Berk A, Kaiser CA. Molecular Cell Biology. 7th ed. New York: WH Freeman and Company. 2013: 1147-1148
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