BRCA2

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&nbsp;BRCA2 is a human tumour suppressor gene that is located on chromosome 13. It produces a 3418 amino acid protein. There is a 59% homology with mouse and even so, most regions have weak conservation. The gene is associated with various intracellular proteins including Ras51 (involved in DNA repair), BARD1, p53 (involved in maintaining genome integrity, cell cycle checkpoint and promotor of apoptosis) and p21 (a cell cycle inhibitor).<ref>Duncan J A, Reeves J R, Cooke T J. BRCA1 and BRCA2 proteins: roles in health and disease. Journal of Clinical Pathology</ref>  
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BRCA2 is a human [[Tumour suppressor gene|tumour suppressor gene]] that is located on [[Chromosome 13|chromosome 13]]. It produces a 3418 [[Amino acid|amino acid]] long [[Protein|protein]]. There is a 59% [[Homologues|homology]] with mouse and even so, most regions have weak conservation. The [[gene|gene]] is associated with various [[Intracellular protein|intracellular proteins]] including [[Ras51|Ras51]] (involved in [[DNA repair|DNA repair]]), [[Bard1|BARD1]], [[P53|p53]] (involved in maintaining genome integrity, cell cycle checkpoint and promotor of [[apoptosis|apoptosis]]) and [[P21|p21]] (a cell cycle inhibitor)<ref>Duncan J A, Reeves J R, Cooke T J. BRCA1 and BRCA2 proteins: roles in health and disease. Journal of Clinical Pathology</ref>.
  
 
The gene was discovered because of the increased amount of mutations in patients with breast cancer<ref>Alberts B, Johnson A, Lewis J, Morgan D, Raff M, Roberts K, Walter P. Molecular Biology of the Cell. 6th Ed, New York: Garland Science. 2015</ref>.  
 
The gene was discovered because of the increased amount of mutations in patients with breast cancer<ref>Alberts B, Johnson A, Lewis J, Morgan D, Raff M, Roberts K, Walter P. Molecular Biology of the Cell. 6th Ed, New York: Garland Science. 2015</ref>.  
 
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Latest revision as of 07:14, 20 October 2018

BRCA2 is a human tumour suppressor gene that is located on chromosome 13. It produces a 3418 amino acid long protein. There is a 59% homology with mouse and even so, most regions have weak conservation. The gene is associated with various intracellular proteins including Ras51 (involved in DNA repair), BARD1, p53 (involved in maintaining genome integrity, cell cycle checkpoint and promotor of apoptosis) and p21 (a cell cycle inhibitor)[1].

The gene was discovered because of the increased amount of mutations in patients with breast cancer[2].

References:

  1. Duncan J A, Reeves J R, Cooke T J. BRCA1 and BRCA2 proteins: roles in health and disease. Journal of Clinical Pathology
  2. Alberts B, Johnson A, Lewis J, Morgan D, Raff M, Roberts K, Walter P. Molecular Biology of the Cell. 6th Ed, New York: Garland Science. 2015
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