Bacterial chromosome replication

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The majority of bacterial chromosomes are circular in composition. Replication of these circular bacterial chromosomes is initiated at a unique site in the DNA called the "Origin of Replication" or "OriC". Replication proceeds from this point bi-directionally from the origin (OriC) to the terminus referred to as "TerC". There are, therefore, two sites of DNA synthesis at structures called replication forks [1][2]


  1. Alberts B, Johnson A, Lewis J et al. Molecular Biology of the Cell 4th Edition. 2002. New York, Garland Science.
  2. Jon M Kaguni, DnaA: Controlling the Initiation of Bacterial DNA Replication and More. Annu. Rev. Microbiol. 2006. 60: 351-71
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