Barr body

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(Created page with "A Barr body is an inactivated X chromosome in a female somatic cell. It becomes inactivated by the process of lyonization; the pr...")
 
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A Barr body is an inactivated X [[Chromosome|chromosome]] in a female [[Somatic_cells|somatic cell]]. It becomes inactivated by the process of [[Lyonization|lyonization]]; the process is there to insure only one X chromosome is active. It is initiated from a site called the XIC ([[X_inactivation_centre|X inactivation centre]])
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A Barr body is an inactivated X [[Chromosome|chromosome]] in a female [[Somatic cells|somatic cell]]. It becomes inactivated by the process of [[Lyonization|lyonization]]; the process is there to insure only one X chromosome is active. It is initiated from a site called the XIC ([[X inactivation centre|X inactivation centre]])  
  
<ref>http://www.nature.com/articles/nrg2987</ref>. The key products from this site are the non-coding RNA transcripts [[Xist|Xist]] and [[Tsix|Tsix]]. Xist work by coating the X outwards leading to it becoming [[Heterochromatin|heterochromatin]]. Not all genes however are silenced and about 10-15% escape inactivation<ref>Alberts B, Johnson A, Lewis J, Raff M, Roberts K and Walter P (2008) Molecular Biology of The Cell, 5th edition, New York: Garland Science</ref>.
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<ref>http://www.nature.com/articles/nrg2987</ref>. The key products from this site are the non-coding RNA transcripts [[Xist|Xist]] and [[Tsix|Tsix]]. Xist work by coating the X outwards leading to it becoming [[Heterochromatin|heterochromatin]]. Not all genes however are silenced and about 10-15% escape inactivation<ref>Alberts B, Johnson A, Lewis J, Raff M, Roberts K and Walter P (2008) Molecular Biology of The Cell, 5th edition, New York: Garland Science</ref>.  
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Revision as of 12:42, 27 November 2017

A Barr body is an inactivated X chromosome in a female somatic cell. It becomes inactivated by the process of lyonization; the process is there to insure only one X chromosome is active. It is initiated from a site called the XIC (X inactivation centre)

[1]. The key products from this site are the non-coding RNA transcripts Xist and Tsix. Xist work by coating the X outwards leading to it becoming heterochromatin. Not all genes however are silenced and about 10-15% escape inactivation[2].

 

 


Cite error: <ref> tags exist, but no <references/> tag was found
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