CAMP
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| − | Cyclic AMP (cAMP) or cyclic adenosine monophosphate acts as a [[Secondary messenger|secondary messenger]] and is used in cell signalling. It can be deactivated by [[Phosphodiesterase|phosphodiesterase]] ([[Phosphodiesterase|PDE]]) into [[AMP|AMP]]. cAMP can activate [[Protein kinase A|protein kinase A]] ([[Protein kinase A|PKA]]) by binding to it's regulatory subunits to produce catalytic subunits. These catalytic subunits can then go on to phosphorylate other proteins, creating a signalling cascade<ref>Alberts Moleucular Biology of the cell 5th edition - page 895</ref>. [[ATP|ATP]] is converted to cAMP by [[Adenylyl cyclase|adenylyl cyclase]], cAMP is then used in a range of signalling pathways. | + | Cyclic AMP (cAMP) or cyclic adenosine monophosphate acts as a [[Secondary messenger|secondary messenger]] and is used in cell signalling. It can be deactivated by [[Phosphodiesterase|phosphodiesterase]] ([[Phosphodiesterase|PDE]]) into [[AMP|AMP]]. cAMP can activate [[Protein kinase A|protein kinase A]] ([[Protein kinase A|PKA]]) by binding to it's regulatory subunits to produce catalytic subunits. These catalytic subunits can then go on to phosphorylate other proteins, creating a signalling cascade<ref>Alberts Moleucular Biology of the cell 5th edition - page 895</ref>. [[ATP|ATP]] is converted to cAMP by [[Adenylyl cyclase|adenylyl cyclase]], cAMP is then used in a range of signalling pathways. <br> |
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Revision as of 10:35, 18 November 2013
Cyclic AMP (cAMP) or cyclic adenosine monophosphate acts as a secondary messenger and is used in cell signalling. It can be deactivated by phosphodiesterase (PDE) into AMP. cAMP can activate protein kinase A (PKA) by binding to it's regulatory subunits to produce catalytic subunits. These catalytic subunits can then go on to phosphorylate other proteins, creating a signalling cascade[1]. ATP is converted to cAMP by adenylyl cyclase, cAMP is then used in a range of signalling pathways.
References:
- ↑ Alberts Moleucular Biology of the cell 5th edition - page 895
