CAMP

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Cyclic AMP (cAMP) or cyclic adenosine monophosphate acts as a [[Secondary messenger|secondary messenger]]&nbsp;and is used in cell signalling. It can be deactivated by [[Phosphodiesterase|phosphodiesterase]] ([[Phosphodiesterase|PDE]]) into [[AMP|AMP]]. cAMP can activate [[Protein kinase A|protein kinase A]] ([[Protein kinase A|PKA]]) by binding to it's regulatory subunits to produce catalytic subunits. These catalytic subunits can then go on to phosphorylate other proteins, creating a signalling cascade<ref>Alberts Moleucular Biology of the cell 5th edition - page 895</ref>.&nbsp;[[ATP|ATP]] is converted to cAMP by [[Adenylyl cyclase|adenylyl cyclase]], cAMP is then used in a range of signalling pathways.&nbsp;<br>  
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Cyclic AMP (cAMP) or cyclic adenosine monophosphate acts as a [[Secondary messenger|secondary messenger]]&nbsp;and is used in cell signalling. It can be deactivated by [[Phosphodiesterase|phosphodiesterase]] ([[Phosphodiesterase|PDE]]) into [[AMP|AMP]]. cAMP can activate [[Protein kinase A|protein kinase A]] ([[Protein kinase A|PKA]]) by binding to it's regulatory subunits which activates and release the catalytic subunits. These active catalytic subunits can then go on to phosphorylate other proteins, creating a signalling cascade<ref>Alberts Moleucular Biology of the cell 5th edition - page 895</ref>.&nbsp;[[ATP|ATP]] is converted to cAMP by [[Adenylyl cyclase|adenylyl cyclase]], cAMP is then used in a range of signalling pathways.&nbsp;<br>  
  
 
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Revision as of 14:35, 25 November 2013

Cyclic AMP (cAMP) or cyclic adenosine monophosphate acts as a secondary messenger and is used in cell signalling. It can be deactivated by phosphodiesterase (PDE) into AMP. cAMP can activate protein kinase A (PKA) by binding to it's regulatory subunits which activates and release the catalytic subunits. These active catalytic subunits can then go on to phosphorylate other proteins, creating a signalling cascade[1]ATP is converted to cAMP by adenylyl cyclase, cAMP is then used in a range of signalling pathways. 

References:

  1. Alberts Moleucular Biology of the cell 5th edition - page 895
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