COX enzyme

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COX or cyclo-oxygenase enzymes produce prostaglandins which promote inflammatory actions such as pain, inflammation and fever essential for the mechanisms involved in healing and recovery[1]. There are two COX enzymes, COX-1 and COX-2. They can be inhibited by non-steroidal anti-inflammatory drugs (NSAIDS) such as ibuprofen, paracetamol and mefenamic acid. The analgesic action of nonsteroidal anti-inflammatory drugs (NSAIDs) has been explained on the basis of their inhibition of these enzymes, COX-1 and COX-2, that synthesize prostaglandins.


  1. Omudhome Ogbru P. NSAIDs: Drug List, Names, and Side Effects [Internet]. MedicineNet. 2017 [cited 1 December 2017]. Available from:
  2. Cashman J. The Mechanisms of Action of NSAIDs in Analgesia. Drugs [Internet]. 1996 [cited 3 December 2017];52(Supplement 5):13-23. Available from:
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