Centrosome

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A centrosome is a region in the cytoplasm of a cell which is in close proximity to a nucleus [1]. The centrosome contains a pair of centrioles which play an essential role in the formation of the mitotic spindle during DNA replication.

The inner region of the centrosome is called the pericentriolar matrix, which envelopes the centrioles found in the centrosome [2]. From the matrix, an array of microtubules form the mitotic spindle at the correct stage during cell division.

In the majority of eukaryotic cells, duplication of the centrosome starts in the later stages of G1 and is completed during the synthesis stages of mitosis [3].

References

  1. Hartl et al. 2006, Essential Genetics p460, 4th edition : Jones and Bartlett Publishers
  2. Alberts et al. 2008, Molecular Biology of the Cell p1076, 5th edition, New York : Garland Science
  3. Hartl et al. 2006, Essential Genetics p460, 4th edition : Jones and Bartlett Publishers
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