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Cholecystokinin (CCK), previously known as pancreozymin, is a straight chained polypeptide which acts as a stimulus for bile production in the digestive system[1]. This digestive hormone is secreted from the I-cells of the duodenum lining accordingly with the presence of proteins and fats in the stomach. The hormonal stimulus causes the liver and gall bladder (through contraction) to secrete bile essential for digestion and lipid absorption, and the pancreas to release pancreatic juices. CCK release is regulated and blocked by the somatostatin hormone[2]. The predominant receptor of the cholecystokinin in the digestive system is the CCKB receptor, followed by the CCKA receptor which is found on the pancreatic acinar cells[3].

Cholecystokinin has also been understood to be present in the brain, however less is known about its neurotransmitter abilities. High levels of CCK are thought to be responsible for short-term hunger satiation. The associated receptor needed for its function in the brain is for the most part the CCKB receptor, not the CCKA receptor[4].


  1. Encyclopaedia Britannica. (2014) Cholecystokinin (CCK)(hormone). [online]. Cholecystokinin (CCK) Available at: <> [26/11/2014]
  2. Society for Endocrinology. (2013) Cholecystokinin. [online]. Available at: <> [26/11/2014]
  3. Bowen, R. (2001) Cholecystokinin. [online], Available at: <>[26/11/2014]
  4. Bowen, R. (2001) Cholecystokinin. [online]. Available at: <> [26/11/2014]
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