Clonal selection gives rise to a diverse of unique antigen receptors. However, self-recognising receptors are made as well. If native antigens i.e. on a tissue surface is recognised, antigen could bind and attack native organs. That's why Clonal Deletion is important as during the development of lymphocytes, these self-reacting antigen receptors are removed before they can mature.
- ↑ (1) K. Murphy, C. Weaver. Janeway's Immunobiology; 9th Edition; Garland Science, Taylor and Francis Group, LLC; 15-16p.