Closed complex

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The closed complex refers to a state in prokaryotic gene expression whereby the RNA Holoenzyme (RNA polymerase with the associated sigma factor) is bound to the DNA[1]. The enzyme binds to the -35 and -10 promoter regions these are hexamers- sequences of six base pairs[2]. After around 10 base transcriptions the sigma factor disassociates from the RNA and elongation continues. This state is referred to as the open complex[3].

References

  1. B Alberts, A Johnson, J Lewis, D Morgan, M Raff, K Roberts, P Walter. Molecular Biology of The Cell. 6th Ed. Abingdon: Garland Science, Taylor and Francis Group, LLC. 2015.
  2. A Kanhere, M Bansal. Structural properties of promoters: similarities and differences between prokaryotes and eukaryotes. Nucleic Acid Research 2005; 33(10): 3165-3175.
  3. B Alberts, A Johnson, J Lewis, D Morgan, M Raff, K Roberts, P Walter. Molecular Biology of The Cell. 6th Ed. Abingdon: Garland Science, Taylor and Francis Group, LLC. 2015.
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