Clotting factors

From The School of Biomedical Sciences Wiki
(Difference between revisions)
Jump to: navigation, search
m (Reference added)
m (Grammar)
 
(One intermediate revision by one user not shown)
Line 1: Line 1:
Blood coagulation is the transformation of [[Blood|blood]] as a liquid into a solid gel-like blood "clot". A clot is formed when [[Platelets|platelets]] stick to [[Collagen|collagen]] exposed by a disrupted blood vessel lining. Other platelets then bind to the initial platelets to form what is called a [[Platelet plug|platelet plug]]. The platelet plug is limited to the disrupted area and does not spread to the normal unaffected tissue. Clotting occurs on top of the platelet plug when [[Fibrinogen|Fibrinogen]] (a large soluble [[Protein]]) is converted into [[Fibrin monomers|Fibrin monomers]] (an insoluble thread-like molecule) by [[Thrombin|thrombin]]. Fibrin monomers are then crosslinked into Fibrin polymers in the presence of [[Factor XIIIa|factor XIIIa]] and [[Calcium|Ca<sup>2+</sup>]].&nbsp;<ref>Factor XIIIa [Internet]. Pathologyoutlines.com. 2017 [cited 3 December 2017]. Available from: http://pathologyoutlines.com/topic/stainsfactorxiiia.html</ref><br><br><references />
+
Blood coagulation is the transformation of [[Blood|blood]]&nbsp;from a liquid into a solid gel-like blood "clot". A clot is formed when [[Platelets|platelets]] stick to [[Collagen|collagen]] exposed by a disrupted blood vessel lining. Other platelets then bind to the initial platelets to form what is called a [[Platelet plug|platelet plug]]. The platelet plug is limited to the disrupted area and does not spread to the normal unaffected tissue. Clotting occurs on top of the platelet plug when [[Fibrinogen|Fibrinogen]] (a large soluble [[Protein]]) is converted into [[Fibrin monomers|Fibrin monomers]] (an insoluble thread-like molecule) by [[Thrombin|thrombin]]. Fibrin monomers are then crosslinked into Fibrin polymers in the presence of [[Factor XIIIa|factor XIIIa]] and [[Calcium|Ca<sup>2+</sup>]]<ref>Factor XIIIa [Internet]. Pathologyoutlines.com. 2017 [cited 3 December 2017]. Available from: http://pathologyoutlines.com/topic/stainsfactorxiiia.html</ref>.
 +
 
 +
=== References  ===
 +
 
 +
<references />

Latest revision as of 17:53, 16 November 2018

Blood coagulation is the transformation of blood from a liquid into a solid gel-like blood "clot". A clot is formed when platelets stick to collagen exposed by a disrupted blood vessel lining. Other platelets then bind to the initial platelets to form what is called a platelet plug. The platelet plug is limited to the disrupted area and does not spread to the normal unaffected tissue. Clotting occurs on top of the platelet plug when Fibrinogen (a large soluble Protein) is converted into Fibrin monomers (an insoluble thread-like molecule) by thrombin. Fibrin monomers are then crosslinked into Fibrin polymers in the presence of factor XIIIa and Ca2+[1].

References

  1. Factor XIIIa [Internet]. Pathologyoutlines.com. 2017 [cited 3 December 2017]. Available from: http://pathologyoutlines.com/topic/stainsfactorxiiia.html
Personal tools
Namespaces
Variants
Actions
Navigation
Toolbox