Cystic fibrosis

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[[Gene therapy|Gene Therapy]]  
 
[[Gene therapy|Gene Therapy]]  
  
[[Pharmacotherapy|Pharmacotherapy]]  
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[[Pharmacotherapy of Cystic Fibrosis|Pharmacotherapy]]  
  
 
[[Alternative Channel Therapy|Alternative Channel Therapy]]  
 
[[Alternative Channel Therapy|Alternative Channel Therapy]]  

Revision as of 11:45, 8 November 2010

Contents

Cystic Fibrosis

Cystic Fibrosis is an autosomal recessive disease located on chromosome 7. Cystic Fibrosis is caused by a mutation to the CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) channel. The most common mutation is ΔF508, accounting for 70% of mutations in the Caucasin UK population, in which the triplet code for the amino acid phenylalanine is deleted, disrupting Cl- transport. This mutation belongs to the Class II group of mutations causing Cystic Fibrosis.


Classes of CFTR Mutations


Class I: Premature Stop Codons

Class II: Abnormal Processing

Class III: Altered Regulation

Class IV: Conductance Defect

Class V: Reduced Protein Synthesis

 

Approaches to Treatment

Lung Function

Physiotherapy and mucolytics

Oral and Inhaled Antibotics

Anti-Inflammatory Drugs

Lung Transplant

Gene Therapy

Pharmacotherapy

Alternative Channel Therapy


Pancreatic Function

Pancreatic Enzyme Replacement

Nutrional Regime

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