DNA binding domain
From The School of Biomedical Sciences Wiki
A DNA binding domain (DBD) is part of a protein with a high affinity for DNA. For example, transcription factors. DBDs have a minimum of one motif which can bind to non-sequence specific or sequence specific DNA. Structural motifs can interact with single stranded and double stranded DNA. The functions of DBDs include allowing structural changes to take place to a protein and to allow regulation of transcription[1].
Some common examples of DBDs include:
- helix-turn-helix
- Helix-turn-helixzinc finger
- Zinc fingerwinged helix
- Winged fingerhelix-loop-helix, which is present in some transcription factors.
- Leucine Zipper
- Homeodomain
References:
- ↑ L. Swint-Kruse and K. S. Matthews. Curr Opin Microbiol. Allostery in the Lac1/ GalR Family: Variations on a Theme. 2009 Apr; 12(2): 129–137
