DNA replication

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DNA replication is a duplication process where exact copies of DNA within cells are replicated, with very low error rate. They typically occur at a rate of 1 in 109 bases per replication. In Mitosis, DNA replication occurs during the S phase. DNA must be duplicated before the division takes place to main the chromosomal number of the two daughter cells. At the end of the division, two genetically identical daughter cells are formed. DNA replication is called Semi-conservative replication.

Bacterial enzymes

Unlike DNA replication in Eukaryotes (e.g. animals), Bacteria have a limited set of key enzymes associated with this process. These are enumerated below, according to their supposed chronological order during replication in E. coli.


  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Cooper, G. M. (2000). The Cell: Molecular Approach. 2nd Edition. Washington, D.C: ASM Press.
  2. Messer, W., Blaesing, F., Majka, J., Nardmann, J., Schaper, S., Schmidt, A., Seitz, H., Speck, C., Tüngler, D., Wegrzyn, G., Weigel, C., Welzeck, M., Zakrzewska-Czerwinska, J.,(1999). Functional domains of DnaA proteins. Available at: http://www.sciencedirect.com/science/article/pii/S0300908499002151 (last assessed on 29/11/12).
  3. Benkovic, S. J, Valentine, A. M., and Salinas, F. (2001). Replisome-mediated DNA replication.
  4. Berg, M. J., Tymoczko, J. L., and Stryer, L. (2002). Biochemistry. 2nd Edition. New York: Freeman and Co.


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