Denature

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When a [[protein|protein]] is changed in shape and "unfolded", it is said to be denatured.  This can occur in a number of ways, from a change in environmental factors (i.e. high/low temperature) to the addition of different chemicals (i.e. [[solvent|solvents]]), causing breaking and changing of integral [[bond|bonds]] within the protein.  
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When a [[Protein|protein]] is changed in shape and "unfolded", it is said to be denatured.  This can occur in a number of ways, from a change in environmental factors (i.e. high/low temperature) to the addition of different chemicals (i.e. [[Solvent|solvents]]), causing breaking and changing of integral [[Bond|bonds]] within the protein.  
  
 
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Denaturing is particularly important to consider when studying [[Enzyme|enzymes]]- If a protein's [[Enzyme active site|active site is]] changed so that it is no longer [[Complementary|complementary]] to it's [[Substrate|substrate]] then it cannot carry out it's function correctly <ref>Alberts, B. Johnson, A. Lewis, J. Raff, M. Roberts, K. Walter, P (2008). Molecular biology of the cell. 5th ed. New York: Garland Science. 130.</ref>.
  
Denaturing is particularly important to consider when studying [[Enzyme|enzymes]]- If a protein's [[Enzyme_active_site|active site ]]is changed so that it is no longer [[complementary|complementary]] to it's [[Substrate|substrate]] then it cannot carry out it's function correctly.
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=== References ===
  
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<references />
  
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Alberts, B. Johnson, A. Lewis, J. Raff, M. Roberts, K. Walter, P (2008). Molecular biology of the cell. 5th ed. New York: Garland Science. 130.
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Revision as of 10:01, 22 October 2012

When a protein is changed in shape and "unfolded", it is said to be denatured.  This can occur in a number of ways, from a change in environmental factors (i.e. high/low temperature) to the addition of different chemicals (i.e. solvents), causing breaking and changing of integral bonds within the protein.

Denaturing is particularly important to consider when studying enzymes- If a protein's active site is changed so that it is no longer complementary to it's substrate then it cannot carry out it's function correctly [1].

References

  1. Alberts, B. Johnson, A. Lewis, J. Raff, M. Roberts, K. Walter, P (2008). Molecular biology of the cell. 5th ed. New York: Garland Science. 130.


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