Disulphide bridges

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A disulphide bridge can also be called a [[Disulphide bond|disulphide bond]]. It is the name of the [[Covalent bond|covalent bond]] that is formed when two thiol groups, SH groups, undergo [[Oxidation|oxidation]] and a bond forms between the two [[Sulphur|sulphur]] atoms. In the formation of this type of bond, two [[Protons|protons]] and two [[Electron|electron]]s are produced as biproducts.
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See [[Disulphide_bond|disulphide bond ]]
 
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Disulphide bonds are often present in [[Tertiary Protein Structure|tertiary protein structure]]&nbsp;between [[Cysteine|cysteine]]&nbsp;residues, as they help to stabilise the protein. The S-S bonds are formed as part of the folding of the&nbsp;protein into its final 3D&nbsp;structure in the&nbsp;[[Endoplasmic reticulum]]<ref>http://www.ncbi.nlm.nih.gov/pubmed/10754564</ref>.
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The disulphide&nbsp;bonds only occur on the extracellular domains of a protein, as in the [[Cytosol]]&nbsp;(a reducing environment) the bonds become unstable and break.
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= References  =
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<references />
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Revision as of 21:31, 22 November 2011

See disulphide bond 

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