EPP

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EPPs (end plate potential) are the [[Depolarisation|depolarisations]] in the [[Skeletal_Muscle|skeletal muscle]] caused by [[Neurotransmitters|neurotransmitters]] such as [[Acetylcholine|Ach]] binding to the [[Postsynaptic_membrane|postsynaptic membrane]] in the [[Neuromuscular junction|neuromuscular junction]].  
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EPPs (end plate potential) are the [[Depolarisation|depolarisations]] in the [[Skeletal Muscle|skeletal muscle]] caused by [[Neurotransmitters|neurotransmitters]] such as [[Acetylcholine|Ach]] binding to the [[Postsynaptic membrane|postsynaptic membrane]] in the [[Neuromuscular junction|neuromuscular junction]].  
  
When Ach is released from the [[Presynaptic_membrane|presynaptic membrane]], it binds to channel-shaped [[Receptors|receptor]]&nbsp;molecules on the [[End plate|end plate]], opening the channels and allowing positively charged [[Sodium ions|sodium ions]] to flow into the [[Muscle cell|muscle cell]], which causes the&nbsp;membrane to depolarise slightly.&nbsp;An [[Enzyme|enzyme]] called [[Acetylcholinesterase|acetylcholinesterase]]&nbsp;then rapidly degrades the [[Acetylcholinesterase|acetylcholine]], so they can diffuse back to the presynaptic knob, closing the channels and allowing the membrane to return to its previous polarised state. <ref>Alberts, Johnson, Lewis, Morgan, Raff, Roberts and Walter (2015) Molecular biology of the cell 6th Edition. New York. Garland Science, Taylor and Francis Group.</ref><br>
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When Ach is released from the [[Presynaptic membrane|presynaptic membrane]], it binds to channel-shaped [[Receptors|receptor]] molecules on the [[End plate|end plate]], opening the channels and allowing positively charged [[Sodium ions|sodium ions]] to flow into the [[Muscle cell|muscle cell]], which causes the membrane to depolarise slightly. An [[Enzyme|enzyme]] called [[Acetylcholinesterase|acetylcholinesterase]] then rapidly degrades the [[Acetylcholinesterase|acetylcholine]], so they can diffuse back to the presynaptic knob, closing the channels and allowing the membrane to return to its previous polarised state<ref>Alberts, Johnson, Lewis, Morgan, Raff, Roberts and Walter (2015) Molecular biology of the cell 6th Edition. New York. Garland Science, Taylor and Francis Group.</ref>.
  
=== References===
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=== References ===
  
 
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Revision as of 20:48, 4 December 2017

EPPs (end plate potential) are the depolarisations in the skeletal muscle caused by neurotransmitters such as Ach binding to the postsynaptic membrane in the neuromuscular junction.

When Ach is released from the presynaptic membrane, it binds to channel-shaped receptor molecules on the end plate, opening the channels and allowing positively charged sodium ions to flow into the muscle cell, which causes the membrane to depolarise slightly. An enzyme called acetylcholinesterase then rapidly degrades the acetylcholine, so they can diffuse back to the presynaptic knob, closing the channels and allowing the membrane to return to its previous polarised state[1].

References

  1. Alberts, Johnson, Lewis, Morgan, Raff, Roberts and Walter (2015) Molecular biology of the cell 6th Edition. New York. Garland Science, Taylor and Francis Group.
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