Endonucleases

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&nbsp;A class of [[Nucleases|nuclease]]&nbsp;which [[Hydrolysis|hydrolyses]] the middle of the [[Polynucleotide Chain|polynucleotide chain]]&nbsp;of a [[Nucleic acids|nucleic acid]]<ref>Alberts B [et al] (2008) Molecular Biology of the Cell, Fifth Edition, New York:Garland Science</ref>.  
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A class of [[Nucleases|nuclease]]&nbsp;which [[Hydrolysis|hydrolyses]] the middle of the [[Polynucleotide Chain|polynucleotide chain]]&nbsp;of a [[Nucleic acids|nucleic acid]]<ref>Alberts B [et al] (2008) Molecular Biology of the Cell, Fifth Edition, New York:Garland Science</ref>, by cleavage of the [[Phosphodiester bond|phosphodiester bond]].&nbsp;Endonucleases can be non-specific (cleaving indiscriminately along the polynucleotide) or they can be specific, cutting at certain sites which are recognised by the [[Enzyme|enzyme]]; these are called [[Restriction endonucleases|restriction endonucleases]].<ref>Cox M, Nelson DR, Lehninger AL (2005). Lehninger principles of biochemistry. San Francisco: W.H. Freeman. p. 952.</ref>
  
 
=== References  ===
 
=== References  ===
  
 
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Revision as of 20:25, 4 December 2016

A class of nuclease which hydrolyses the middle of the polynucleotide chain of a nucleic acid[1], by cleavage of the phosphodiester bond. Endonucleases can be non-specific (cleaving indiscriminately along the polynucleotide) or they can be specific, cutting at certain sites which are recognised by the enzyme; these are called restriction endonucleases.[2]

References

  1. Alberts B [et al] (2008) Molecular Biology of the Cell, Fifth Edition, New York:Garland Science
  2. Cox M, Nelson DR, Lehninger AL (2005). Lehninger principles of biochemistry. San Francisco: W.H. Freeman. p. 952.
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