Endonucleases

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A class of nuclease which hydrolyses the middle of the polynucleotide chain of a nucleic acid[1], by cleavage of the phosphodiester bond. Endonucleases can be non-specific (cleaving indiscriminately along the polynucleotide) or they can be specific, cutting at certain sites which are recognised by the enzyme; these are called restriction endonucleases.[2]

References

  1. Alberts B [et al] (2008) Molecular Biology of the Cell, Fifth Edition, New York:Garland Science
  2. Cox M, Nelson DR, Lehninger AL (2005). Lehninger principles of biochemistry. San Francisco: W.H. Freeman. p. 952.
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