Endothelial Cell-Cell Junction

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Cell-cell junction are importance in [[Cells|cells]] for the transfer of important biological and biochemical substances between surrounding cells. &nbsp;It enables [[Cells|cells]] to form attachment among each other and in the process aid cell-cell communication. &nbsp;This communication in the form of intracelluar [[Cell signalling|signalling]] controls the activities of cells such as [[Apoptosis|apoptosis]], cell growth and [[Gene expression|gene expression]]&nbsp;<ref>Elisabetta, D. (2004)"Endothelial Cell–Cell Junctions: Happy Together". Nature Reviews Molecular Cell Biology. Vol 5, April, 261-270.</ref>. &nbsp;Cell-cell junction occurs in most[[Eukaryotic cells|eukaryotic]] tissues such as in [[Epithelial cells|epithelial and]] endothelial cells. &nbsp;Cell junction of the [[Endothelial tissue|endothelial tissues]] functions in the regulation of the passage of cellular substances such as [[Blood|blood]] [[Proteins|proteins]] into [[Blood vessels|blood vessels]]<br>  
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Cell-cell junction are importance in [[Cells|cells]] for the transfer of important biological and biochemical substances between surrounding cells. &nbsp;It enables [[Cells|cells]] to form attachment among each other and in the process aid cell-cell communication. &nbsp;This communication in the form of intracelluar [[Cell signalling|signalling]] controls the activities of cells such as [[Apoptosis|apoptosis]], cell growth and [[Gene expression|gene expression]]&nbsp;<ref>Elisabetta, D. (2004)"Endothelial Cell–Cell Junctions: Happy Together". Nature Reviews Molecular Cell Biology. Vol 5, April, 261-270.</ref>. &nbsp;Cell-cell junction occurs in most&nbsp;[[Eukaryotic cells|eukaryotic]] tissues such as in [[Epithelial cells|epithelial and]] endothelial cells. &nbsp;Cell junction of the [[Endothelial tissue|endothelial tissues]] functions in the regulation of the passage of cellular substances such as [[Blood|blood]] [[Proteins|proteins]] into [[Blood vessels|blood vessels]]<br>  
  
 
=== Types of Endothelial cell Junctions:  ===
 
=== Types of Endothelial cell Junctions:  ===

Latest revision as of 12:50, 28 November 2014

Cell-cell junction are importance in cells for the transfer of important biological and biochemical substances between surrounding cells.  It enables cells to form attachment among each other and in the process aid cell-cell communication.  This communication in the form of intracelluar signalling controls the activities of cells such as apoptosis, cell growth and gene expression [1].  Cell-cell junction occurs in most eukaryotic tissues such as in epithelial and endothelial cells.  Cell junction of the endothelial tissues functions in the regulation of the passage of cellular substances such as blood proteins into blood vessels

Types of Endothelial cell Junctions:

As with epithelial cell junction, endothelial cell junction are also classified based on their structure and role into four main types.  However, desmosomes present in epithelial cells are absent in endothelial cells except cells of the lymphatic systems; having desmosome-like structures [2]. Desmosomes are intracellular junctions which promote cell to cell adhesion and also anchor the plasma membrane to the intermediate filaments of the cytoskeleton [3]. According to Elisabetta et al., (1995) [4] endothelial cells are therefore, classified into[5][6][7][8][9][10][11]:

  1. Tight Junction (also known as Zonnula Occludens)
  2. Adherence Junction
  3. Gap Junctions
  4. Syndesmos

References

  1. Elisabetta, D. (2004)"Endothelial Cell–Cell Junctions: Happy Together". Nature Reviews Molecular Cell Biology. Vol 5, April, 261-270.
  2. Elisabetta, D. (2004)"Endothelial Cell–Cell Junctions: Happy Together". Nature Reviews Molecular Cell Biology. Vol 5, April, 261-270.
  3. Delva E, Tucker DK, Kowalczyk AP.. 2009. The Desmosome. [ONLINE] Available at: http://www.ncbi.nlm.nih.gov/pubmed/20066089. [Accessed 21 October 13].
  4. Elisabetta, D., Monica, C., and Maria, G.L., (1995) "Endothelial Cell-to-Cell Junctions". The FASEB Journal. Vol. 9, No. 10, July, 910-918.
  5. http://www.ascb.org/bioeducate/images/FawcettTheCellPDFs/FawcettTheCellChapter3.pdf
  6. http://www.ascb.org/bioeducate/images/FawcettTheCellPDFs/FawcettTheCellChapter3.pdf
  7. http://cronodon.com/files/Building_bodies_-_cell_junctions.pdf
  8. http://cronodon.com/files/Building_bodies_-_cell_junctions.pdf
  9. http://www.sciencedirect.com/science/article/pii/S0960982208012396
  10. http://www.sciencedirect.com/science/article/pii/S0960982208012396
  11. http://www.ncbi.nlm.nih.gov/books/NBK26857/

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