Enzyme-coupled Receptor

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Enzyme-coupled receptors are a major kind of cell membrane receptors characterized either by having an intrinsic enzymatic activity on their cytosolic domain or by being coupled with an enzyme. They have two main domains: ligand binding site on the outside and an enzyme binding (catalytic) domain on the inside of the cell. Enzyme-coupled receptors are single-pass transmembrane proteins[1]. These receptors are very diverse but they can be classified in six main classes[2]:


  1. Alberts B, Johnson A, Lewis J, Morgan D, Raff M, Roberts K, Walter P. Molecular Biology of the cell: Sixth Edition: 6th Ed. New York: Garland Science. 2015
  2. Alberts, et al. Molecular Biology of the Cell. 5th ed. Garland Science. 2008

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