Enzyme-linked receptors

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 Enzyme- linked receptors are one of 3 classes of cell surface receptors (the other 2 are [[Ion-channel-coupled receptor|ion channel coupled]] and [[G-protein Coupled Receptor|G-protein coupled receptors]]- GPCRs). They are single-span transmembrane proteins and their cytosolic domain has intrinsic enzymatic activity or is associated with an enzyme. Activation of such receptors is usually carried out by promotion of dimerisation initiated by binding of [[Ligand|ligand]] molecules. The most common type of enzyme- linked receptors is [[Receptor tyrosine kinases|receptor tyrosine kinase]] (RTK). The family of these receptors includes [[Insulin receptor|Insulin receptor]], as well as many [[Growth factor receptor|growth factor receptors]]. Other more common classes of enzyme- linked receptors include tyrosine- kinase associated receptors and receptor serine/threonine kinases.  
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[[Enzyme|Enzyme]]-linked receptors are one of 3 classes of cell surface receptors (the other 2 are [[Ion-channel-coupled receptor|ion channel coupled]] and [[G-protein Coupled Receptor|G-protein coupled receptors]] (GPCRs)). They are single-span [[transmembrane proteins|transmembrane proteins]] and their [[cytosolic domain|cytosolic domain]] has intrinsic enzymatic activity or is associated with an enzyme. Activation of such receptors is usually carried out by the promotion of dimerisation initiated by binding of [[Ligand|ligand]] molecules. The most common type of enzyme-linked receptors is [[Receptor tyrosine kinases|receptor tyrosine kinase]] (RTK). The family of these receptors includes [[Insulin receptor|Insulin receptor]], as well as many [[Growth factor receptor|growth factor receptors]]. Other more common classes of enzyme-linked receptors include tyrosine-kinase-associated receptors and receptor serine/threonine kinases.  
  
Enzyme-linked receptors and GPCRs often take part in the same [[Cell signalling pathways|signalling pathways]].<ref>Alberts B, Johnson A, Lewis J, Morgan D, Raff M, Roberts K, Walter P, Molecular biology of the cell, 6th edition, New York: Garland Science, Taylor and Francis Group, 2015,pages: 818, 850, 879</ref>  
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Enzyme-linked receptors and GPCRs often take part in the same [[Cell signalling pathways|signalling pathways]]<ref>Alberts B, Johnson A, Lewis J, Morgan D, Raff M, Roberts K, Walter P, Molecular biology of the cell, 6th edition, New York: Garland Science, Taylor and Francis Group, 2015,pages: 818, 850, 879</ref>.
 
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Latest revision as of 09:40, 3 December 2018

Enzyme-linked receptors are one of 3 classes of cell surface receptors (the other 2 are ion channel coupled and G-protein coupled receptors (GPCRs)). They are single-span transmembrane proteins and their cytosolic domain has intrinsic enzymatic activity or is associated with an enzyme. Activation of such receptors is usually carried out by the promotion of dimerisation initiated by binding of ligand molecules. The most common type of enzyme-linked receptors is receptor tyrosine kinase (RTK). The family of these receptors includes Insulin receptor, as well as many growth factor receptors. Other more common classes of enzyme-linked receptors include tyrosine-kinase-associated receptors and receptor serine/threonine kinases.

Enzyme-linked receptors and GPCRs often take part in the same signalling pathways[1].

References

  1. Alberts B, Johnson A, Lewis J, Morgan D, Raff M, Roberts K, Walter P, Molecular biology of the cell, 6th edition, New York: Garland Science, Taylor and Francis Group, 2015,pages: 818, 850, 879
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