Exosome

From The School of Biomedical Sciences Wiki
Jump to: navigation, search

The exosome is the main 3' to 5' Exonuclease in the cell. It is involved in the RNA turnover and processing in the cell[1].

The exosome is a multisubunit complex. The subunits mean that there is multiple nuclease activites. Rrp44 is used in a large number of diverse RNA processing and degradation events in eukaryotes[2].

Rrp6 is another "nuclear-specific catalytic component of the RNA exosome complex"[3] and is another subunit which provides nuclease activity. The rest of the subunits function in RNA binding/unwinding. 

References

  1. https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-016-0268-z
  2. https://www.ncbi.nlm.nih.gov/pubmed/22833611
  3. https://www.uniprot.org/uniprot/Q12149

 
Personal tools
Namespaces
Variants
Actions
Navigation
Toolbox