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Fibronectin is an extracellular matrix protein that helps cells attach to the matrix by acting as a "linker" that binds to a cell-surface integrin molecule on one end and to a matrix component (such as collagen) on the other end[1]. Fibronectin proteins are composed of a linear arrangement of repeating stuctural molecules that are classed into domains referred to as fibronectin repeats. The exact order of these repeats varies due to alternative splicing[2].


  1. Alberts, Bray, Hopkin, Johnson, Lewis, Raff, Roberts, Walter 2014, Essential Cell Biology, 4th edn, Garland Science, New York.
  2. Cassimeris L, Lingappa VR, Plopper G. Lewin's Cells. 2nd Ed, Sudbury:Jones and Bartlett. 2011
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