Frame shift

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A frame shift is a form of [[Mutation|mutation]] that can occur in living organisms, this occurs by the insertion or deletion of a number of bases that arent divisible by the number three. This can cause a different [[Amino_acids|amino acids]] to be formed from the original code. This can result in a different protein being produced which does not perform the same function as it once did therefore becoming a transcuted [[Protein|protein]]. There is a possibility that the new [[Codon|codon]] formed can be a [[Stop codon|stop codon]] (one in twenty chance) which will stop the [[Polypeptide|polypeptide chain]] from fully being produced. Frame shift mutuations can occur through slippages at repeat sequences during replication. It is a very unstable mutation and many different [[Codon|codons]] can be produced from the wild type genetic code.  
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A frame shift is a form of [[Mutation|mutation]] that can occur in living organisms, this occurs by the insertion or deletion of a number of bases that arent divisible by the number three. This type of mutation can often cause different [[Amino acids|amino acids]] to be coded for from the original code, however, due to the degenerate nature of the genetic code an insertion mutation may not always result in a different amino acid being coded for. For example, the codons TTT and TTC (where T = thymine and C = cytosine) both code for the amino acid Phenylalanine. When the resulting amino acids ''are'' different,  the mutation may result in a different protein being produced which does not perform the same function as before. This is known as a transcuted [[Protein|protein]]. There is a one in twenty chance that the new [[Codon|codon]] formed may be a [[Stop codon|stop codon]] (also known as a nonsense mutation) which will stop the [[Polypeptide|polypeptide chain]] from fully being produced. Frame shift mutuations can occur through slippages at repeat sequences during replication. It is a very unstable mutation and many different [[Codon|codons]] can be produced from the wild type genetic code.  
  
A frame shift mutation is one of many mutations including, base pair changes, deletion, insertion, inversion and duplications.
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A frame shift mutation is one of many mutations including; base pair changes, deletion, insertion, inversion and duplications.

Revision as of 12:11, 16 November 2015

A frame shift is a form of mutation that can occur in living organisms, this occurs by the insertion or deletion of a number of bases that arent divisible by the number three. This type of mutation can often cause different amino acids to be coded for from the original code, however, due to the degenerate nature of the genetic code an insertion mutation may not always result in a different amino acid being coded for. For example, the codons TTT and TTC (where T = thymine and C = cytosine) both code for the amino acid Phenylalanine. When the resulting amino acids are different,  the mutation may result in a different protein being produced which does not perform the same function as before. This is known as a transcuted protein. There is a one in twenty chance that the new codon formed may be a stop codon (also known as a nonsense mutation) which will stop the polypeptide chain from fully being produced. Frame shift mutuations can occur through slippages at repeat sequences during replication. It is a very unstable mutation and many different codons can be produced from the wild type genetic code.

A frame shift mutation is one of many mutations including; base pair changes, deletion, insertion, inversion and duplications.

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