G-protein Coupled Receptor

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The G-protein-coupled receptor (GPCR) is a seven transmembrane spanning receptor that interacts with G-protein in the process of cell signalling. It constitutes along with ion-channel-coupled receptors and enzyme-coupled receptors a major class of cell surface-receptor[1].

Classification

Over 800 G-protein-coupled receptors have been identified (more than half of them being olfactory receptors) and phylogenetic studies carried out[2]. From these studies the GPCRs can be classified in five main families: 

References

  1. Alberts, et al. Molecular Biology of the Cell. 5th ed. Garland Science. 2008
  2. Fredriksson R, Lagerström MC, Lundin LG, Schiöth HB. The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints.Mol Pharmacol. 2003 Jun;63(6):1256-72.

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