GTPase

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Overview

GTPases are a group of enzymes which hydrolyse GTP to GDP (a phosphate group is removed). They play an important roll in cell signalling pathways for example, GTP/GDP bound G proteins have intrinsic GTPase activity to slowly reset themselves to their resting state state once it has fullfilled its function [1] (Please note not all G proteins have an active intrinsic GTPase activity and require association with GAP in order to hydrolyse GTP. They are also involved in the synthesis of proteins at the ribosome [2]. They also have roles in vesicle movement and cell division.

The alpha subunit of the heterotrimeric G-protein is a GTPase. [3]

References

  1. Berg J, Tymoczko J and Stryer L, 2007. Biochemistry, 6th Edition, New York: W.H.Freeman & Co Ltd. (page 387)
  2. Berg J, Tymoczko J and Stryer L, 2007. Biochemistry, 6th Edition, New York: W.H.Freeman & Co Ltd. (page 881)
  3. Hardin J., Bertoni G., Kleinsmith L., 2011 Beckers World Of The Cell. 8th Edition, San Fransisco: Pearson Education
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