Gene knockout

From The School of Biomedical Sciences Wiki
(Difference between revisions)
Jump to: navigation, search
(Created page with " A gene knockout is a deletion mutation where part of a gene is missing, making the wildtype nonfunctional. Gen...")
 
Line 1: Line 1:
&nbsp;A gene knockout is a [[Deletion_mutation|deletion mutation]]&nbsp;where part of a [[Gene|gene]]&nbsp;is missing, making the [[Wild_-_type|wildtype]]&nbsp;nonfunctional. Gene knockout is a technique often used when producing [[Transgenic_Organism|transgenic]]&nbsp;animals, as the removal of a [[Gene|gene]]&nbsp;can give important information about it's function. Gene knockoutis also often used to produce[[Transgenic_Organism|transgenic]] mice with knockouts of [[Homologous|homologs]] of genes associated with human disease that act as models for humans diseases.<ref name="1">D.L. Hartl. M. Ruvolo. Genetics: Analysis of Genes and Genomes. Jones and Bartlett learning. 2012.</ref>
+
&nbsp;A gene knockout is a [[Deletion_mutation|deletion mutation ]]where part of a [[Gene|gene]] is missing, making the [[Wild_-_type|wildtype]] nonfunctional. Gene knockout is a technique often used when producing [[Transgenic_Organism|transgenic]] animals to study the function of specific [[Gene|genes]], as loss of a certian funtion in the transgenic animal can give important information about the function of the [[Gene|gene]] that has been knocked out. Gene knockout is also often used to produce transgenic mice with knockouts of [[Homologous|homologs]] of [[Gene|genes]] associated with human disease that act as models for humans diseases<ref>D.L. Hartl. M. Ruvolo. Genetics: Analysis of Genes and Genomes. Jones and Bartlett learning. 2012.</ref>.
  
References
+
== References ==
  
<ref>D.L. Hartl, M Ruvolo. Genetics: Analysis of Genes and Genomes. 8th edition. Jones and Bartlett. 2012.</ref>
+
<references />

Revision as of 13:39, 4 December 2016

 A gene knockout is a deletion mutation where part of a gene is missing, making the wildtype nonfunctional. Gene knockout is a technique often used when producing transgenic animals to study the function of specific genes, as loss of a certian funtion in the transgenic animal can give important information about the function of the gene that has been knocked out. Gene knockout is also often used to produce transgenic mice with knockouts of homologs of genes associated with human disease that act as models for humans diseases[1].

References

  1. D.L. Hartl. M. Ruvolo. Genetics: Analysis of Genes and Genomes. Jones and Bartlett learning. 2012.
Personal tools
Namespaces
Variants
Actions
Navigation
Toolbox