Gene knockout

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&nbsp;A gene knockout is a [[Deletion_mutation|deletion mutation]]&nbsp;where part of a [[Gene|gene]]&nbsp;is missing, making the [[Wild_-_type|wildtype]]&nbsp;nonfunctional. Gene knockout is a technique often used when producing [[Transgenic_Organism|transgenic]]&nbsp;animals, as the removal of a [[Gene|gene]]&nbsp;can give important information about it's function. Gene knockoutis also often used to produce[[Transgenic_Organism|transgenic]] mice with knockouts of [[Homologous|homologs]] of genes associated with human disease that act as models for humans diseases.<ref name="1">D.L. Hartl. M. Ruvolo. Genetics: Analysis of Genes and Genomes. Jones and Bartlett learning. 2012.</ref>
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A gene knockout is a [[Deletion mutation|deletion mutation]] where part of a [[Gene|gene]] is missing, making the [[Wild - type|wildtype]] nonfunctional. Gene knockout is a technique often used when producing [[Transgenic Organism|transgenic]] animals to study the function of specific [[Gene|genes]], as loss of a certian funtion in the [[Transgenic Organism|transgenic]] animal can give important information about the function of the [[Gene|gene]] that has been knocked out. Gene knockout is a potent and irreversible means to inactivate a [[Genes|gene]]<ref>Transgenic Animal Technology (Third Edition). A Laboratory Handbook. Carl A. Pinkert</ref>. Gene knockout is also often used to produce [[Transgenic mice|transgenic mice]] with knockouts of [[Homologous|homologs]] of [[Gene|genes]] associated with human disease that act as models for humans diseases<ref>D.L. Hartl. M. Ruvolo. Genetics: Analysis of Genes and Genomes. Jones and Bartlett learning. 2012.</ref>.
  
References
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=== References ===
  
<ref>D.L. Hartl, M Ruvolo. Genetics: Analysis of Genes and Genomes. 8th edition. Jones and Bartlett. 2012.</ref>
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<references />

Latest revision as of 17:54, 2 December 2017

A gene knockout is a deletion mutation where part of a gene is missing, making the wildtype nonfunctional. Gene knockout is a technique often used when producing transgenic animals to study the function of specific genes, as loss of a certian funtion in the transgenic animal can give important information about the function of the gene that has been knocked out. Gene knockout is a potent and irreversible means to inactivate a gene[1]. Gene knockout is also often used to produce transgenic mice with knockouts of homologs of genes associated with human disease that act as models for humans diseases[2].

References

  1. Transgenic Animal Technology (Third Edition). A Laboratory Handbook. Carl A. Pinkert
  2. D.L. Hartl. M. Ruvolo. Genetics: Analysis of Genes and Genomes. Jones and Bartlett learning. 2012.
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