A gene knockout is a deletion mutation where part of a gene is missing, making the wildtype nonfunctional. Gene knockout is a technique often used when producing transgenic animals to study the function of specific genes, as loss of a certian funtion in the transgenic animal can give important information about the function of the gene that has been knocked out. Gene knockout is also often used to produce transgenic mice with knockouts of homologs of genes associated with human disease that act as models for humans diseases.
- ↑ D.L. Hartl. M. Ruvolo. Genetics: Analysis of Genes and Genomes. Jones and Bartlett learning. 2012.