Genetic mutation

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'''Genetic mutation- '''this term indicates an alteration to base sequence in [[DNA|DNA]] of an organism which results in a mutant [[Allele|allele]] of a [[Gene|gene]] i.e. an allele that occurs in less than 1% of population.The change is heritable and can be passed on to offspring if fixed into the parental [[Genome|genome]]. Mutations can vary depending on the type of genomic alteration:  
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'''Genetic mutation- '''this term indicates an alteration to base sequence in [[DNA|DNA]] of an organism which results in a mutant [[Allele|allele]] of a [[Gene|gene]] i.e. an allele that occurs in less than 1% of population. The change is heritable and can be passed on to offspring if fixed into the parental [[Genome|genome]]. Mutations can vary depending on the type of genomic alteration:  
  
-addition  
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*addition  
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*deletion
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*substitution
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*rearrangement of bases.
  
-deletion
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To investigate the events leading to mutation we can look at the 3 types of mutagenesis process:
  
-substitution
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*spontaneous (no mutation causing agent)
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*induced (a foreign genome introduced e.g.in the laboratory)
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*directed (''in vitro'' change to the genome).
  
-rearrangement of bases.
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We can calculate the rate of mutation occurance using an equation from Poisson distribution:
  
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'''P<sub>0</sub>=e<sup>-mN</sup>'''<sup></sup>
  
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where P<sub>0</sub> is the probability of seeing no mutations, N is the number of cells per culture and m is the mutation rate <ref>Genetics, 1987, Geoffrey Zubay</ref><ref>Encyclopedia of Genetics,Volume 3, 2002, S.Brenner,J.H. Miller</ref>.
  
To investigate the events leading to mutation we can look at mutagenesis process. There are three types:
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=== References  ===
  
-spontaneous (no mutation causing agent)
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<references />  
 
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-induced (a foreign genome introduced e.g.in the laboratory)
+
 
+
-directed (in vitro change to genome).
+
 
+
 
+
 
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We can calculate the rate of mutation occurance using an equation from Poisson distribution:
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'''P<sub>0</sub>=e<sup>-mN</sup>'''<sup></sup>&nbsp;
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<br>
 
<br>
 
where P<sub>0</sub> is the probability of seeing no mutations, N is the number of cells per culture and m is the mutation rate.
 
 
 
 
'''References:'''
 
 
Genetics, 1987, Geoffrey Zubay
 
 
Encyclopedia of Genetics,Volume 3, 2002, S.Brenner,J.H. Miller
 

Latest revision as of 09:34, 18 November 2017

Genetic mutation- this term indicates an alteration to base sequence in DNA of an organism which results in a mutant allele of a gene i.e. an allele that occurs in less than 1% of population. The change is heritable and can be passed on to offspring if fixed into the parental genome. Mutations can vary depending on the type of genomic alteration:

To investigate the events leading to mutation we can look at the 3 types of mutagenesis process:

We can calculate the rate of mutation occurance using an equation from Poisson distribution:

P0=e-mN

where P0 is the probability of seeing no mutations, N is the number of cells per culture and m is the mutation rate [1][2].

References

  1. Genetics, 1987, Geoffrey Zubay
  2. Encyclopedia of Genetics,Volume 3, 2002, S.Brenner,J.H. Miller


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