Genetic mutation

From The School of Biomedical Sciences Wiki
(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
 
'''Genetic mutation- '''this term indicates an alteration to base sequence in [[DNA|DNA]] of an organism which results in a mutant [[Allele|allele]] of a [[Gene|gene]] i.e. an allele that occurs in less than 1% of population.The change is heritable and can be passed on to offspring if fixed into the parental [[Genome|genome]]. Mutations can vary depending on the type of genomic alteration:  
 
'''Genetic mutation- '''this term indicates an alteration to base sequence in [[DNA|DNA]] of an organism which results in a mutant [[Allele|allele]] of a [[Gene|gene]] i.e. an allele that occurs in less than 1% of population.The change is heritable and can be passed on to offspring if fixed into the parental [[Genome|genome]]. Mutations can vary depending on the type of genomic alteration:  
  
-addition  
+
*addition
 
+
*deletion
-deletion  
+
*substitution
 
+
*rearrangement of bases.
-substitution  
+
 
+
-rearrangement of bases.  
+
 
+
 
+
  
 
To investigate the events leading to mutation we can look at mutagenesis process. There are three types:  
 
To investigate the events leading to mutation we can look at mutagenesis process. There are three types:  
  
-spontaneous (no mutation causing agent)  
+
*spontaneous (no mutation causing agent)
 
+
*induced (a foreign genome introduced e.g.in the laboratory)
-induced (a foreign genome introduced e.g.in the laboratory)  
+
*directed (in vitro change to genome).<br>
 
+
-directed (in vitro change to genome).  
+
 
+
 
+
  
 
We can calculate the rate of mutation occurance using an equation from Poisson distribution:  
 
We can calculate the rate of mutation occurance using an equation from Poisson distribution:  
Line 25: Line 16:
 
'''P<sub>0</sub>=e<sup>-mN</sup>'''<sup></sup>&nbsp;  
 
'''P<sub>0</sub>=e<sup>-mN</sup>'''<sup></sup>&nbsp;  
  
<br>
+
where P<sub>0</sub> is the probability of seeing no mutations, N is the number of cells per culture and m is the mutation rate <ref>Genetics, 1987, Geoffrey Zubay</ref><ref>Encyclopedia of Genetics,Volume 3, 2002, S.Brenner,J.H. Miller</ref>.<br>  
 +
===
  
where P<sub>0</sub> is the probability of seeing no mutations, N is the number of cells per culture and m is the mutation rate.
+
<references /><br>
  
 
+
<br>
 
+
'''References:'''
+
 
+
Genetics, 1987, Geoffrey Zubay
+
 
+
Encyclopedia of Genetics,Volume 3, 2002, S.Brenner,J.H. Miller
+

Revision as of 07:19, 25 November 2012

Genetic mutation- this term indicates an alteration to base sequence in DNA of an organism which results in a mutant allele of a gene i.e. an allele that occurs in less than 1% of population.The change is heritable and can be passed on to offspring if fixed into the parental genome. Mutations can vary depending on the type of genomic alteration:

To investigate the events leading to mutation we can look at mutagenesis process. There are three types:

We can calculate the rate of mutation occurance using an equation from Poisson distribution:

P0=e-mN 

where P0 is the probability of seeing no mutations, N is the number of cells per culture and m is the mutation rate [1][2].

===
  1. Genetics, 1987, Geoffrey Zubay
  2. Encyclopedia of Genetics,Volume 3, 2002, S.Brenner,J.H. Miller


Personal tools
Namespaces
Variants
Actions
Navigation
Toolbox